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The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity.

Abstract:

Anthocyanidin synthase (ANS), an iron(II) and 2-oxoglutarate (2OG) dependent oxygenase, catalyses the penultimate step in anthocyanin biosynthesis by oxidation of the 2R,3S,4S-cis-leucoanthocyanidins. It has been believed that in vivo the products of ANS are the anthocyanidins. However, in vitro studies on ANS using optically active cis- and trans-leucocyanidin substrates identified cyanidin as only a minor product; instead both quercetin and dihydroquercetin are products with the distributio...

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Publication status:
Published

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Journal:
Bioorganic and medicinal chemistry letters
Volume:
13
Issue:
21
Pages:
3853-3857
Publication date:
2003-11-05
DOI:
EISSN:
1464-3405
ISSN:
0960-894X
URN:
uuid:61110cdc-4bcf-49c7-ad74-17cb8cfebd62
Source identifiers:
32512
Local pid:
pubs:32512

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