- Abstract:
-
Alpha-latrotoxin (LTX) causes massive release of neurotransmitters via a complex mechanism involving (i) activation of receptor(s) and (ii) toxin insertion into the plasma membrane with (iii) subsequent pore formation. Using cryo-electron microscopy, electrophysiological and biochemical methods, we demonstrate here that the recently described toxin mutant (LTXN4C) is unable to insert into membranes and form pores due to its inability to assemble into tetramers. However, this mutant still bind...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m210395200
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 278
- Issue:
- 33
- Pages:
- 31058-31066
- Publication date:
- 2003-08-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:610cd61f-3778-4612-84a7-8944608eaa14
- Source identifiers:
-
329224
- Local pid:
- pubs:329224
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Mutant alpha-latrotoxin (LTXN4C) does not form pores and causes secretion by receptor stimulation: this action does not require neurexins.
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