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Spatial reference memory in GluR-A-deficient mice using a novel hippocampal-dependent paddling pool escape task.

Abstract:

Genetically modified mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit, GluR-A (GluR1), and deficient in hippocampal CA3-CA1 long-term potentiation (LTP), were assessed on a novel, hippocampal-dependent spatial reference memory, paddling pool escape task. The mice were required to use the extramaze cues around the laboratory to find a hidden escape tube that was in a constant location at one of 12 possible positions around the perimeter of the pad...

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Publication status:
Published

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Publisher copy:
10.1002/hipo.10168

Authors


Schmitt, WB More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Sprengel, R More by this author
Seeburg, PH More by this author
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Journal:
Hippocampus
Volume:
14
Issue:
2
Pages:
216-223
Publication date:
2004
DOI:
EISSN:
1098-1063
ISSN:
1050-9631
URN:
uuid:6100add0-6e32-4494-8c50-1918b81c87d1
Source identifiers:
15629
Local pid:
pubs:15629

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