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Thesis

An analysis of non-coding RNAs in Plasmodium falciparum and their potential role in antigenic variation.

Abstract:

A major virulence factor of the human malaria parasite Plasmodium falciparum is Plasmodium falciparum erythrocyte membrane protein 1(PfEMP-1). This protein is inserted into the erythrocyte membrane, giving cytoadherence properties. A family of genes called var, located sub-telomerically and in chromosome central clusters encode this protein. Var genes are expressed in a mutually exclusive manner, how this is controlled is unclear. A non-coding RNA (ncRNA...

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Institution:
University of Oxford
Research group:
Molecular Parasitology Group
Oxford college:
St Catherine's College
Department:
Radcliffe Department of Medicine

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:60ea27e2-1129-4914-8abd-cfad018e0353
Local pid:
ora:7187

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