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Ahaptoglobinaemia in Melanesia: DNA and malarial antibody studies.

Abstract:

To assess the relative contributions of genetic and acquired factors, particularly malaria, to the high frequencies of ahaptoglobinaemia found in Melanesia we have performed DNA and malarial antibody studies in a population from Vanuatu. No gene deletion or rearrangement was found on gene mapping in any ahaptoglobinaemic individual and the frequencies of the Hp1 and Hp2 alleles in the ahaptoglobinaemic group were similar to controls. However, antibodies to Plasmodium falciparum were significa...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Whitehouse, DB More by this author
Bowden, DK More by this author
Hopkinson, DA More by this author
Draper, CC More by this author
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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:
81
Issue:
4
Pages:
573-577
Publication date:
1987
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
URN:
uuid:60e846b4-9486-4f21-83e4-ea43a12c1bb5
Source identifiers:
35317
Local pid:
pubs:35317

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