- Abstract:
-
Epithelial cells lining the intestinal mucosa play a critical role in mucosal immune homeostasis. The inability to culture primary intestinal epithelial cells (IEC) in vitro, limited their use in ex vivo IEC functional studies. Recently, a method for developing primary intestinal crypt-like 3D structures termed organoids was described. The aim of this project was to establish 2D primary IEC monolayers that could be used to dissect the innate immune response of primar...
Expand abstract - Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- University of Oxford
- Copyright date:
- 2016
Thesis
Primary intestinal epithelial cell response to Helicobacter hepaticus in an ex vivo setting
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