- Abstract:
-
T cells require dual stimulation to become activated. When T cells encounter antigen-presenting cells, both the T cell receptor (TCR) and the CD28 coreceptor are ligated and activated. Michel and Acuto discuss how the adaptor SLP-76, which is recruited to the activated TCR complex, and the Rho family guanosine triphosphatase exchanger Vav-1, which is recruited by the CD28 receptor and TCR, may form a macromolecular complex that results in T cells activation. Vav-1 may serve as a central integ...
Expand abstract - Publisher copy:
- 10.1126/stke.2002.144.pe35
-
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- Journal:
- Science's STKE : signal transduction knowledge environment
- Volume:
- 2002
- Issue:
- 144
- Pages:
- pe35
- Publication date:
- 2002-08-05
- DOI:
- EISSN:
-
1525-8882
- ISSN:
-
1945-0877
- URN:
-
uuid:60da582a-c0bc-4a7a-be94-915dc8159ef3
- Source identifiers:
-
16796
- Local pid:
- pubs:16796
- Copyright date:
- 2002
Journal article
CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?
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