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CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?

Abstract:

T cells require dual stimulation to become activated. When T cells encounter antigen-presenting cells, both the T cell receptor (TCR) and the CD28 coreceptor are ligated and activated. Michel and Acuto discuss how the adaptor SLP-76, which is recruited to the activated TCR complex, and the Rho family guanosine triphosphatase exchanger Vav-1, which is recruited by the CD28 receptor and TCR, may form a macromolecular complex that results in T cells activation. Vav-1 may serve as a central integ...

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Publisher copy:
10.1126/stke.2002.144.pe35

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Science's STKE : signal transduction knowledge environment
Volume:
2002
Issue:
144
Pages:
pe35
Publication date:
2002-08-05
DOI:
EISSN:
1525-8882
ISSN:
1945-0877
URN:
uuid:60da582a-c0bc-4a7a-be94-915dc8159ef3
Source identifiers:
16796
Local pid:
pubs:16796

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