Journal article
Theoretical insights into the retinal dynamics of VEGF in patients treated with ranibizumab, based on an ocular pharmacokinetic/pharmacodynamic model
- Abstract:
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Neovascular age-related macular degeneration (wet AMD) results from the pathological angiogenesis of choroidal capillaries, which leak fluid within or below the macular region of the retina. The current standard of care for treating wet AMD utilizes intravitreal injections of anti-VEGF antibodies or antibody fragments to suppress ocular VEGF levels. While VEGF suppression has been demonstrated in wet AMD patients by serial measurements of free-VEGF concentrations in aqueous humor samples, it ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 861.7KB)
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(Accepted manuscript, pdf, 5.6MB)
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- Publisher copy:
- 10.1021/acs.molpharmaceut.8b00280
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Authors
Funding
Roche Pharma Research and Early Development
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Medical Research Council
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Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Molecular Pharmaceutics Journal website
- Volume:
- 15
- Issue:
- 7
- Pages:
- 2770–2784
- Publication date:
- 2018-05-07
- Acceptance date:
- 2018-05-07
- DOI:
- EISSN:
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1543-8392
- ISSN:
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1543-8384
- Source identifiers:
-
846589
Item Description
- Pubs id:
-
pubs:846589
- UUID:
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uuid:60a5f9aa-709f-4374-8065-8c26eee7c9e0
- Local pid:
- pubs:846589
- Deposit date:
- 2018-05-08
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 American Chemical Society. This is the accepted manuscript version of the article. The final version is available online from American Chemical Society at: https://doi.org/10.1021/acs.molpharmaceut.8b00280
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