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Journal article

Theoretical insights into the retinal dynamics of VEGF in patients treated with ranibizumab, based on an ocular pharmacokinetic/pharmacodynamic model

Abstract:

Neovascular age-related macular degeneration (wet AMD) results from the pathological angiogenesis of choroidal capillaries, which leak fluid within or below the macular region of the retina. The current standard of care for treating wet AMD utilizes intravitreal injections of anti-VEGF antibodies or antibody fragments to suppress ocular VEGF levels. While VEGF suppression has been demonstrated in wet AMD patients by serial measurements of free-VEGF concentrations in aqueous humor samples, it ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/acs.molpharmaceut.8b00280

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Oxford college:
Brasenose College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Role:
Author
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Medical Research Council More from this funder
Roche Pharma Research and Early Development More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Molecular Pharmaceutics Journal website
Volume:
15
Issue:
7
Pages:
2770–2784
Publication date:
2018-05-07
Acceptance date:
2018-05-07
DOI:
EISSN:
1543-8392
ISSN:
1543-8384
Pubs id:
pubs:846589
URN:
uri:60a5f9aa-709f-4374-8065-8c26eee7c9e0
UUID:
uuid:60a5f9aa-709f-4374-8065-8c26eee7c9e0
Local pid:
pubs:846589

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