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Invasive cell migration is initiated by guided growth of long cellular extensions.

Abstract:

The migration of border cells during Drosophila melanogaster oogenesis is a simple and powerful system for studying invasive cell migration in vivo. Border cells are somatic cells that delaminate from the follicular epithelium of an egg chamber and invade the germ line cluster. They migrate between the nurse cells to reach the oocyte, using DE-cadherin for adhesion to the substratum. Border cells take approximately 6 h to migrate a distance of 100 microm. The migration is guided by EGFR (epid...

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Publisher copy:
10.1038/ncb848

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Journal:
Nature cell biology
Volume:
4
Issue:
9
Pages:
715-719
Publication date:
2002-09-05
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
URN:
uuid:60965ead-39fe-4854-9c61-695fceb83805
Source identifiers:
271120
Local pid:
pubs:271120

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