Journal article icon

Journal article

Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development.

Abstract:

BACKGROUND: Mechanistic within-host models relating blood anti-malarial drug concentrations with the parasite-time profile help in assessing dosing schedules and partner drugs for new anti-malarial treatments. A comprehensive simulation study to assess the utility of a stage-specific pharmacokinetic-pharmacodynamic (PK-PD) model for predicting within-host parasite response was performed. METHODS: Three anti-malarial combination therapies were selected: artesunate-mefloquine, dihydroartemisini...

Expand abstract
Publication status:
Published

Actions


Access Document


Files:
Publisher copy:
10.1186/1475-2875-11-303

Authors


Zaloumis, S More by this author
Humberstone, A More by this author
Charman, SA More by this author
Moehrle, J More by this author
Expand authors...
Journal:
Malaria journal
Volume:
11
Issue:
1
Pages:
303
Publication date:
2012
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
URN:
uuid:6093d5c3-7a7d-4520-9477-dd0f87458367
Source identifiers:
379455
Local pid:
pubs:379455

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP