- Abstract:
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Engineered underdominance is one of a number of different gene drive strategies that have been proposed for the genetic control of insect vectors of disease. Here we model a two-locus engineered underdominance based gene drive system that is based on the concept of mutually suppressing lethals. In such a system two genetic constructs are introduced, each possessing a lethal element and a suppressor of the lethal at the other locus. Specifically, we formulate and analyse a population genetics ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.3MB)
-
- Publisher copy:
- 10.1016/j.jtbi.2017.07.014
-
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- Grant:
- MPE is funded through Investigator Award [110117/Z/15/Z] made to LSA
- Grant:
- BBS/E/I/00001892
- Publisher:
- Elsevier Publisher's website
- Journal:
- Journal of Theoretical Biology Journal website
- Volume:
- 430
- Pages:
- 128-140
- Publication date:
- 2017-07-17
- DOI:
- EISSN:
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1095-8541
- ISSN:
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0022-5193
- Pubs id:
-
pubs:709103
- URN:
-
uri:607a962d-9864-45ab-aed3-83095b132c9b
- UUID:
-
uuid:607a962d-9864-45ab-aed3-83095b132c9b
- Local pid:
- pubs:709103
- Language:
- English
- Copyright holder:
- Edgington and Alphey
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 The Authors. Published by Elsevier Ltd.
This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/)
Journal article
Conditions for success of engineered underdominance gene drive systems
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