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Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial

Abstract:

Background: The infection of a participant with norovirus during the adaptive study of interleukin-2 dose on regulatory T cells in type 1 diabetes (DILT1D) allowed a detailed insight into the cellular and cytokine immune responses to this prevalent gastrointestinal pathogen. Methods: Serial blood, serum and peripheral blood mononuclear cell (PBMC) samples were collected pre-, and post-development of the infection. To differentiate between the immune response to norovirus and to control for th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.12688/wellcomeopenres.11300.3

Authors


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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Oliveira, J More by this author
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Challis, B More by this author
Walker, NM More by this author
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Grant:
091157/Z/10/Z], [107212/Z/15/Z], [100140/Z/12/Z], [203141/Z/16/Z]
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Grant:
[9-2011-253], [5-SRA-2015-130-A-N]
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Grant:
Sir Jules Thorn Award for Biomedical Research 2013 [13/JTA]
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Grant:
Cambridge Biomedical Research Centre
Publisher:
F1000Research Publisher's website
Journal:
Wellcome Open Research Journal website
Volume:
2
Pages:
Article: 28
Publication date:
2017
Acceptance date:
2017-07-13
DOI:
ISSN:
2398-502X
Pubs id:
pubs:690120
URN:
uri:606f1917-d03f-48b3-96c0-857664f4767a
UUID:
uuid:606f1917-d03f-48b3-96c0-857664f4767a
Local pid:
pubs:690120

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