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Journal article

Efficient induction of T cells against conserved HIV-1 regions by mosaic vaccines delivered as self-amplifying mRNA

Abstract:

Focusing T cell responses on the most vulnerable parts of HIV-1, the functionally conserved regions of HIV-1 proteins, is likely a key prerequisite for vaccine success. For a T cell vaccine to efficiently control HIV-1 replication, the vaccine-elicited individual CD8+ T cells and as a population have to display a number of critical traits. If any one of these traits is suboptimal, the vaccine is likely to fail. Fine-tuning of individual protective characteristics of T cells will require itera...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.omtm.2018.10.010

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Jenner Institute
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Jenner Institute
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Publisher:
Elsevier Publisher's website
Journal:
Molecular Therapy - Methods and Clinical Development Journal website
Volume:
12
Pages:
32-46
Publication date:
2018-10-26
Acceptance date:
2018-10-21
DOI:
EISSN:
2329-0501
Pubs id:
pubs:951037
URN:
uri:606d8b82-2547-4106-8e0a-4e6dc0e8269d
UUID:
uuid:606d8b82-2547-4106-8e0a-4e6dc0e8269d
Local pid:
pubs:951037

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