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Accumulation of B lymphocytes with a naive, resting phenotype in a subset of hepatitis C patients.

Abstract:

Chronic infection with hepatitis C virus (HCV) is associated with disturbances of B lymphocyte activation and function: autoantibody production, mixed cryoglobulinemia, and B cell lymphomas. It has been proposed that these abnormalities reflect chronic antigenic stimulation or aberrant signaling through the B cell coreceptor, the latter mediated by binding of the HCV E2 glycoprotein to CD81. To test this hypothesis, we measured expression of activation and differentiation markers on periphera...

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Publisher copy:
10.4049/jimmunol.170.6.3429

Authors


Hembrador, E More by this author
Di Bisceglie, AM More by this author
Jacobson, IM More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
170
Issue:
6
Pages:
3429-3439
Publication date:
2003-03-29
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:6066796c-f81e-4380-a2a9-a3f45092e169
Source identifiers:
426422
Local pid:
pubs:426422

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