Is nonangiogenesis a novel pathway for cancer progression? A study using 3-dimensional tumour reconstructions.

Journal article

The nonangiogenic lung tumour is characterized by neoplastic cells co-opting the pre-existent vasculature and filling the alveoli space. 3-dimensional reconstruction of the tumour reveals that this particular tumour progresses without neovascularization and there is no major destruction of the lung's architectural integrity.

Authors: Adighibe, O; Micklem, K; Campo, L; Ferguson, M; Harris, A

• Publication status: Published
• Journal: British journal of cancer
• Volume: 94
• Issue: 8
• Pages: 1176-1179
• Publication date: 2006-04-01
• DOI: 10.1038/sj.bjc.6603039
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Carcinoma, Non-Small-Cell Lung; Neovascularization, Pathologic; Immunohistochemistry; Antigens, CD34; Keratins; Lung Neoplasms; Humans; Disease Progression; Staining and Labeling; Imaging, Three-Dimensional