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Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits

Abstract:

The growth hormone/insulin‐like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF‐related proteins including IGF‐I and IGF‐binding protein‐3 (IGFBP‐3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through genomewide association study of up to 30 884 adults of European ancestry from 21 studies, we confirmed and extended the list of previously identified loci associated with circulating IGF‐I...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1111/acel.12490

Authors


Nethander, M More by this author
Aschard, H More by this author
Bandinelli, S More by this author
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Publisher:
Wiley Publisher's website
Journal:
Aging cell Journal website
Volume:
15
Issue:
5
Pages:
811-824
Publication date:
2016-10-01
Acceptance date:
2016-04-01
DOI:
EISSN:
1474-9726
ISSN:
1474-9718
Pubs id:
pubs:630019
URN:
uri:603b2ab3-90c8-445d-829e-fc70d763c300
UUID:
uuid:603b2ab3-90c8-445d-829e-fc70d763c300
Local pid:
pubs:630019

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