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Mgm101: A double-duty Rad52-like protein.

Abstract:

Mgm101 has well-characterized activity for the repair and replication of the mitochondrial genome. Recent work has demonstrated a further role for Mgm101 in nuclear DNA metabolism, contributing to an S-phase specific DNA interstrand cross-link repair pathway that acts redundantly with a pathway controlled by Pso2 exonuclease. Due to involvement of FANCM, FANCJ and FANCP homologues (Mph1, Chl1 and Slx4), this pathway has been described as a Fanconi anemia-like pathway. In this pathway, Mgm101 ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1080/15384101.2016.1231288

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Funding agency for:
Nosek, J
Grant:
APVV-14-0253
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Funding agency for:
Tomáška, Ľ
Grant:
APVV-15-0022
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Funding agency for:
Chovanec, M
Grant:
APVV-14-0783
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Funding agency for:
McHugh, P
Grant:
MR/L007665/1
Publisher:
Taylor and Francis Publisher's website
Journal:
Cell Cycle Journal website
Volume:
15
Issue:
23
Pages:
3169-3176
Publication date:
2016-09-16
Acceptance date:
2016-08-26
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
Source identifiers:
646002
Language:
English
Keywords:
Pubs id:
pubs:646002
UUID:
uuid:6037d6c2-fefc-47b6-b933-8307b026cb88
Local pid:
pubs:646002
Deposit date:
2016-10-26

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