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Strong HLA class I--restricted T cell responses in dengue hemorrhagic fever: a double-edged sword?

Abstract:

Dengue is an increasingly important cause of morbidity and mortality in the tropics, but vaccine development has been impeded by a poor understanding of disease pathogenesis and, in particular, of immunologic enhancement. In a large case-control study of Vietnamese patients with dengue hemorrhagic fever (DHF), variation at the HLA-A locus was significantly associated with susceptibility to DHF (P=.02), and specific HLA-A susceptibility and resistance alleles were identified. HLA-A-specific ep...

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Publication status:
Published

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Publisher copy:
10.1086/324320

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Journal:
The Journal of infectious diseases
Volume:
184
Issue:
11
Pages:
1369-1373
Publication date:
2001-12-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:60352202-0b1b-4158-ab28-b8d761f13803
Source identifiers:
24840
Local pid:
pubs:24840

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