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Artemisinin resistance and stage dependency of parasite clearance in Falciparum malaria

Abstract:
Background Artemisinin resistance in falciparum malaria is associated with kelch13 propeller mutations, reduced ring stage parasite killing, and, consequently, slow parasite clearance. We assessed how parasite age affects parasite clearance in artemisinin resistance. Methods Developmental stages of Plasmodium falciparum parasites on blood films performed at hospital admission and their kelch13 genotypes were assessed for 816 patients enrolled in a multinatio... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/infdis/jiy673

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Department for International Development More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
219
Issue:
9
Pages:
1483–1489
Publication date:
2019-01-17
Acceptance date:
2018-12-22
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pmid:
30657916
Source identifiers:
965432
Language:
English
Keywords:
Pubs id:
pubs:965432
UUID:
uuid:60320fea-c980-423d-8ae9-5c327f9ae0e6
Local pid:
pubs:965432
Deposit date:
2019-01-21

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