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Expansion of Foxp3(+) T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge.

Abstract:

Candida albicans remains the fungus most frequently associated with nosocomial bloodstream infection. In disseminated candidiasis, the role of Foxp3(+) regulatory T (Treg) cells remains largely unexplored. Our aims were to characterize Foxp3(+) Treg-cell activation in a murine intravenous challenge model of disseminated C. albicans infection, and determine the contribution to disease. Flow cytometric analyses demonstrated that C. albicans infection drove in vivo expansion of a splenic CD4(+) ...

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Publication status:
Published

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Publisher copy:
10.1002/eji.201343604

Authors


Whibley, N More by this author
Maccallum, DM More by this author
Vickers, MA More by this author
Zafreen, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
European journal of immunology
Volume:
44
Issue:
4
Pages:
1069-1083
Publication date:
2014-04-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:60211384-0e9f-456d-a4b8-5725491a072a
Source identifiers:
465771
Local pid:
pubs:465771

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