- Abstract:
-
The aim of this study was to investigate possible regulation of the hyperpolarization-activated current (I(f)) by cytosolic calcium in guinea-pig sino-atrial (SA) node cells. Isolated SA node cells were superfused with physiological saline solution (36 degrees C) and the perforated patch voltage-clamp technique used to record I(f) activated by hyperpolarizing voltage steps. A 10-min loading of SA node cells with the calcium chelator BAPTA (using 10 microM BAPTA-AM) significantly reduced the a...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0008-6363(02)00668-5
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- Journal:
- Cardiovascular research
- Volume:
- 57
- Issue:
- 2
- Pages:
- 497-504
- Publication date:
- 2003-02-05
- DOI:
- EISSN:
-
1755-3245
- ISSN:
-
0008-6363
- URN:
-
uuid:601514ed-c67f-4b55-81c6-7b0c4ecd6042
- Source identifiers:
-
106413
- Local pid:
- pubs:106413
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Modulation of the hyperpolarization-activated current (I(f)) by calcium and calmodulin in the guinea-pig sino-atrial node.
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