Journal article icon

Journal article

Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis.

Abstract:

The activated hepatic stellate cell (HSC) is central to liver fibrosis as the major source of collagens I and III and the tissue inhibitors of metalloproteinase-1 (TIMP-1). During spontaneous recovery from liver fibrosis, there is a decrease of TIMP expression, an increase in collagenase activity, and increased apoptosis of HSC, highlighting a potential role for TIMP-1 in HSC survival. In this report, we use tissue culture and in vivo models to demonstrate that TIMP-1 directly inhibits HSC ap...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.m111490200

Authors


Murphy, FR More by this author
Ratnarajah, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Expand authors...
Journal:
The Journal of biological chemistry
Volume:
277
Issue:
13
Pages:
11069-11076
Publication date:
2002-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:600c77f3-62cb-4501-b89c-4814a1afbabd
Source identifiers:
227316
Local pid:
pubs:227316

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP