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Microtubule polarity and dynamics in the control of organelle positioning, segregation, and cytokinesis in the trypanosome cell cycle.

Abstract:

Trypanosoma brucei has a precisely ordered microtubule cytoskeleton whose morphogenesis is central to cell cycle events such as organelle positioning, segregation, mitosis, and cytokinesis. We have defined microtubule polarity and show the + ends of the cortical microtubules to be at the posterior end of the cell. Measurements of organelle positions through the cell cycle reveal a high degree of coordinate movement and a relationship with overall cell extension. Quantitative analysis of the s...

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Publication status:
Published

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Publisher copy:
10.1083/jcb.128.6.1163

Authors


Robinson, DR More by this author
Sherwin, T More by this author
Ploubidou, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
The Journal of cell biology
Volume:
128
Issue:
6
Pages:
1163-1172
Publication date:
1995-03-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:5ff0e7b1-ace0-4e88-9130-ef48afb82707
Source identifiers:
13170
Local pid:
pubs:13170

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