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Journal article

A high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression.

Abstract:

CD45 (leukocyte common) antigen is a hemopoietic cell-specific tyrosine phosphatase essential for antigen receptor-mediated signaling in lymphocytes. The molecule undergoes complex alternative splicing in the extracellular domain, and different patterns of CD45 splicing are associated with distinct functions. Lack of CD45 leads to severe combined immunodeficiency, and alterations of CD45 splicing, because of a polymorphism in exon 4, have been associated with altered immune function. Here we ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0931490100

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
100
Issue:
10
Pages:
5997-6002
Publication date:
2003-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:5fea7a11-ab39-43cd-b0e2-e875da7c29d2
Source identifiers:
32357
Local pid:
pubs:32357

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