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Stable lines of genetically modified dendritic cells from mouse embryonic stem cells.

Abstract:

BACKGROUND: The capacity to activate naïve T cells sets dendritic cells (DCs) apart from other antigen-presenting cells, making them attractive targets for immune intervention during deleterious immune responses. The inherent resistance of terminally differentiated DCs to conventional strategies for genetic modification has, however, greatly limited our understanding of the molecular mechanisms underlying their function. METHODS AND RESULTS: We report the derivation of long-term cultures of ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Transplantation
Volume:
76
Issue:
3
Pages:
606-608
Publication date:
2003-08-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:5fe9fe79-b788-4e4f-a8f0-3efb7c9200a0
Source identifiers:
30982
Local pid:
pubs:30982

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