Journal article icon

Journal article

High-fat diet disrupts metabolism in two generations of rats in a parent-of-origin specific manner

Abstract:

Experimental and epidemiological evidence demonstrate that ancestral diet might contribute towards offspring health. This suggests that nutrition may be able to modify genetic or epigenetic information carried by germ cells (GCs). To examine if a parental high fat diet (HFD) influences metabolic health in two generations of offspring, GC-eGFP Sprague Dawley rats were weaned onto HFD (45% fat) or Control Diet (CD; 10% fat). At 19 weeks, founders (F0) were bred with controls, establishing the F...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1038/srep31857

Authors


Chambers, TJG More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
Exeter College
ORCID:
0000-0001-7720-0447
Sharpe, RM More by this author
More from this funder
Funding agency for:
Chambers, TJG
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Issue:
31857
Pages:
1-11
Publication date:
2016-08-23
Acceptance date:
2016-07-28
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:640497
URN:
uri:5fe7a941-e88a-4525-acd0-abce05637b3e
UUID:
uuid:5fe7a941-e88a-4525-acd0-abce05637b3e
Local pid:
pubs:640497
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP