- Abstract:
-
BACKGROUND: The interleukin-2-mediated immune response is critical for host defense against infectious pathogens. Cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a suppressor of cytokine signaling, controls interleukin-2 signaling. METHODS: Using a case-control design, we tested for an association between CISH polymorphisms and susceptibility to major infectious diseases (bacteremia, tuberculosis, and severe malaria) in blood samples from 8402 persons in Gambia, Hong Kong, Keny...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1056/nejmoa0905606
-
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- Journal:
- The New England journal of medicine
- Volume:
- 362
- Issue:
- 22
- Pages:
- 2092-2101
- Publication date:
- 2010-06-05
- DOI:
- EISSN:
-
1533-4406
- ISSN:
-
0028-4793
- URN:
-
uuid:5fd54807-f2b9-4f8d-82ce-dbcfd7213faf
- Source identifiers:
-
58604
- Local pid:
- pubs:58604
- Copyright date:
- 2010
Journal article
CISH and susceptibility to infectious diseases.
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