Journal article icon

Journal article

CISH and susceptibility to infectious diseases.

Abstract:

BACKGROUND: The interleukin-2-mediated immune response is critical for host defense against infectious pathogens. Cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a suppressor of cytokine signaling, controls interleukin-2 signaling. METHODS: Using a case-control design, we tested for an association between CISH polymorphisms and susceptibility to major infectious diseases (bacteremia, tuberculosis, and severe malaria) in blood samples from 8402 persons in Gambia, Hong Kong, Keny...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1056/nejmoa0905606

Authors


Vannberg, FO More by this author
Chapman, SJ More by this author
Expand authors...
Journal:
The New England journal of medicine
Volume:
362
Issue:
22
Pages:
2092-2101
Publication date:
2010-06-05
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
URN:
uuid:5fd54807-f2b9-4f8d-82ce-dbcfd7213faf
Source identifiers:
58604
Local pid:
pubs:58604

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP