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Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors

Abstract:

© 2014 Elsevier Ltd. All rights reserved. We report the isolation and structural determination of fourteen iminosugars, containing five pyrrolizidines and five indolizidines, from Castanospermum australe. The structure of a new alkaloid was elucidated by spectroscopic methods as 6,8-diepi-castanospermine (13). Our side-by-side comparison between bicyclic and corresponding monocyclic iminosugars revealed that inhibition potency and spectrum against each enzyme are clearly changed by their core...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Hirokami, Y More by this author
Miyawaki, S More by this author
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Funding agency for:
Fleet, GWJ
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Grant:
Grant-in-Aid for Scientific Research 26460143 to AK
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Grant:
Research Fellowship to GWJF
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Publisher:
Elsevier Publisher's website
Journal:
Phytochemistry Journal website
Volume:
111
Pages:
124-131
Publication date:
2015-03-05
DOI:
ISSN:
0031-9422
URN:
uuid:5fd48e73-d1c4-4738-bdec-e01749ba40c4
Source identifiers:
508889
Local pid:
pubs:508889

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