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An investigation into the role of methylation in mammalian X-chromosome inactivation

Abstract:

X-chromosome inactivation achieves dosage compensation of X-linked genes between male (XY) and female (XX) mammals. This process involves the down-regulation of most, but not all genes on one of the two X-chromosomes in the nucleus of each female somatic cell. The mechanism of X-inactivation has yet to be elucidated in full, but is known to involve the noncoding transcript of theXist gene, DNA methylation, histone hypo-acetylation and the condensation of higher order chromatin. Recent stu...

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Institution:
University of Oxford
Department:
Faculty of Biological Sciences
Publication date:
1999
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
602835121
URN:
uuid:5fd37c27-af19-4bbd-92a7-4c5b846b3a31
Local pid:
td:602835121
Language:
English
Subjects:

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