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Journal article

Self-assembly of a four-helix bundle on a DNA quadruplex.

Abstract:
Come together: A novel method for assembling monomers and controlling structure of a de novo helix bundle protein is described. A guanine (G)-rich oligodeoxynucleotide scaffold forms a hydrogen-bonded DNA quadruplex in the presence of potassium counterions, thereby inducing a helical structure and fourfold stoichiometry in conjugated, amphiphilic peptide sequences. The DNA scaffold shows potential for rapidly assembling designed proteins.
Publication status:
Published

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Publisher copy:
10.1002/anie.200804849

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Angewandte Chemie (International ed. in English)
Volume:
48
Issue:
15
Pages:
2749-2751
Publication date:
2009-01-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:5fce5107-fe8d-4874-8f34-686e2c6fd7ec
Source identifiers:
117476
Local pid:
pubs:117476

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