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Measurement of pH using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging

Abstract:

Altered metabolic phenotypes, with consequential alterations in tissue pH, are commonplace in a number of pathologies. The metabolic reprogramming common in cancer leads to acidification of the tumour microenvironment and alkalosis of the intracellular space, whereas the cessation of blood flow in ischaemic stroke results in systemic acidification of the affected tissue. Thus far, however, measurement of pH is under-utilised as a physiological parameter of interest in the clinic, desp...

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Division:
MSD
Department:
Oncology
Role:
Author

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Supervisor
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Supervisor
Medical Research Council More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:5fca46c6-03de-4f29-abab-b83bada92c87
Deposit date:
2018-08-23

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