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Immunization with live Neisseria lactamica protects mice against meningococcal challenge and can elicit serum bactericidal antibodies.

Abstract:

Natural immunity against Neisseria meningitidis is thought to develop following nasopharyngeal colonization with this bacterium or other microbes expressing cross-reactive antigens. Neisseria lactamica is a commensal of the upper respiratory tract which is often carried by infants and young children; epidemiological evidence indicates that colonization with this bacterium can elicit serum bactericidal activity (SBA) against Neisseria meningitidis, the most validated correlate of protective im...

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Publisher copy:
10.1128/iai.01062-06

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Journal:
Infection and immunity
Volume:
74
Issue:
11
Pages:
6348-6355
Publication date:
2006-11-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:5fc6c40f-ef99-4122-94db-ab036d87f319
Source identifiers:
249492
Local pid:
pubs:249492

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