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Journal article

T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine

Abstract:

IL-23 is a key driver of pathogenic Th17 cell responses. It has been suggested that the transcription factor T-bet is required to facilitate IL-23-driven pathogenic effector functions; however, the precise role of T-bet in intestinal T cell responses remains elusive. Here, we show that T-bet expression by T cells is not required for the induction of colitis or the differentiation of pathogenic Th17 cells but modifies qualitative features of the IL-23-driven colitogenic response by negatively ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms11627

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Role:
Author
ORCID:
0000-0002-1374-0329
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Role:
Author
ORCID:
0000-0001-7902-6024
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
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Wellcome Trust More from this funder
Fondation Louis Jeantet More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
7
Pages:
11627
Publication date:
2016-05-19
Acceptance date:
2016-04-14
DOI:
EISSN:
2041-1723
Pmid:
27193261
Source identifiers:
623480
Language:
English
Keywords:
Pubs id:
pubs:623480
UUID:
uuid:5fb5425b-2c81-4ea9-9342-ed311daa4d09
Local pid:
pubs:623480
Deposit date:
2018-05-15

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