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Modulating effects of plasma containing anti-malarial antibodies on in vitro anti-malarial drug susceptibility in Plasmodium falciparum.

Abstract:

BACKGROUND: The efficacy of anti-malarial drugs is determined by the level of parasite susceptibility, anti-malarial drug bioavailability and pharmacokinetics, and host factors including immunity. Host immunity improves the in vivo therapeutic efficacy of anti-malarial drugs, but the mechanism and magnitude of this effect has not been characterized. This study characterized the effects of 'immune' plasma to Plasmodium falciparumon the in vitro susceptibility of P. falciparum to anti-malarial ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1186/1475-2875-9-326

Authors


Monatrakul, P More by this author
Mungthin, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Krudsood, S More by this author
Udomsangpetch, R More by this author
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Faculty of Tropical Medicine, Mahidol University More from this funder
Wellcome Trust More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Malaria Journal Journal website
Volume:
9
Issue:
1
Pages:
Article: 326
Publication date:
2010
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
URN:
uuid:5fb3b7b5-8dc5-48c4-8196-edc8a6e50827
Source identifiers:
103602
Local pid:
pubs:103602

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