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Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.

Abstract:

BACKGROUND: Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and environmental factors (reproductive, behavioural, and anthropometric risk factors for breast cancer). To test for evidence of gene-environment interactions, we compared genotypic relative risks for breast cancer across the other risk factors in a large UK prospective study. METHODS: We tested gene-environment interactions in 7610 women who develope...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Cancer Epidemiology Unit
Reeves, GK More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Cancer Epidemiology Unit, BHF Centre of Research Excellence
Tipper, SJ More by this author
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Journal:
Lancet
Volume:
375
Issue:
9732
Pages:
2143-2151
Publication date:
2010-06-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:5fae3ff3-efff-45a8-9219-b77503034cb6
Source identifiers:
65262
Local pid:
pubs:65262

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