The oxygen-dependent hydroxylation of proline residues in the alpha subunit of hypoxia-inducible transcription factor (HIFalpha) is central to the hypoxic response in animals. Prolyl hydroxylation of HIFalpha increases its binding to the von Hippel-Lindau protein (pVHL), so signaling for degradation via the ubiquitin-proteasome system. The HIF prolyl hydroxylases (PHDs, prolyl hydroxylase domain enzymes) are related to the collagen prolyl hydroxylases, but form unusually stable complexes with...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
If you are the owner of this record, you can report an update to it here: Report update to this record