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Journal article

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.

Abstract:

The oxygen-dependent hydroxylation of proline residues in the alpha subunit of hypoxia-inducible transcription factor (HIFalpha) is central to the hypoxic response in animals. Prolyl hydroxylation of HIFalpha increases its binding to the von Hippel-Lindau protein (pVHL), so signaling for degradation via the ubiquitin-proteasome system. The HIF prolyl hydroxylases (PHDs, prolyl hydroxylase domain enzymes) are related to the collagen prolyl hydroxylases, but form unusually stable complexes with...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2009.06.002

Authors


Chowdhury, R More by this author
McDonough, MA More by this author
Mecinović, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Flashman, E More by this author
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Journal:
Structure (London, England : 1993)
Volume:
17
Issue:
7
Pages:
981-989
Publication date:
2009-07-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:5fab8675-6d3d-4569-8cc9-d0bfba812b62
Source identifiers:
34797
Local pid:
pubs:34797

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