- Abstract:
-
Extracellular stability, endocytic escape, intracellular DNA release and nuclear translocation of DNA are all critical properties of non-viral vector/DNA particles. We have evaluated a (Lys)(16)-based linear, reducible polycation (RPC) in combination with an acid-dependent, anionic fusogenic peptide for gene delivery to dividing and post-mitotic cells. The RPC was formed from Cys(Lys)(16)Cys monomers. Molecular weight was 24,000 Da, corresponding to an average of 10.5 peptide monomers per RPC...
Expand abstract - Publisher copy:
- 10.1016/j.bbagen.2007.06.009
-
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- Journal:
- Biochimica et biophysica acta
- Volume:
- 1770
- Issue:
- 9
- Pages:
- 1331-1337
- Publication date:
- 2007-09-05
- DOI:
- ISSN:
-
0006-3002
- URN:
-
uuid:5f9fd3fd-a32a-4399-a275-4ab0affbcc3e
- Source identifiers:
-
504373
- Local pid:
- pubs:504373
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
(LYS)(16)-based reducible polycations provide stable polyplexes with anionic fusogenic peptides and efficient gene delivery to post mitotic cells.
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