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(LYS)(16)-based reducible polycations provide stable polyplexes with anionic fusogenic peptides and efficient gene delivery to post mitotic cells.

Abstract:

Extracellular stability, endocytic escape, intracellular DNA release and nuclear translocation of DNA are all critical properties of non-viral vector/DNA particles. We have evaluated a (Lys)(16)-based linear, reducible polycation (RPC) in combination with an acid-dependent, anionic fusogenic peptide for gene delivery to dividing and post-mitotic cells. The RPC was formed from Cys(Lys)(16)Cys monomers. Molecular weight was 24,000 Da, corresponding to an average of 10.5 peptide monomers per RPC...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Biochimica et biophysica acta
Volume:
1770
Issue:
9
Pages:
1331-1337
Publication date:
2007-09-05
DOI:
ISSN:
0006-3002
URN:
uuid:5f9fd3fd-a32a-4399-a275-4ab0affbcc3e
Source identifiers:
504373
Local pid:
pubs:504373

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