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Membrane-type 1 matrix metalloproteinase and cell migration.

Abstract:

Membrane-type 1 matrix metalloproteinase (MT1-MMP) is an integral membrane proteinase that performs processing of cell surface proteins and degradation of extracellular matrix (ECM) components. Through these proteolytic events, MT1-MMP regulates various cellular functions, including ECM turnover, promotion of cell migration and invasion, and morphogenic responses to extracellular stimuli. MT1-MMP has to be regulated strictly to accomplish its function appropriately at various steps, including...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Biochemical Society symposium
Volume:
70
Issue:
70
Pages:
253-262
Publication date:
2003
EISSN:
1744-1439
ISSN:
0067-8694
URN:
uuid:5f940e8b-98f7-44f5-a3b7-f8056213ee73
Source identifiers:
224391
Local pid:
pubs:224391

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