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A comparison of GluR-A-deficient and wild-type mice on a test battery assessing sensorimotor, affective, and cognitive behaviors.

Abstract:

Previous studies have demonstrated a spatial working memory deficit in glutamate receptor (GluR)-A (GluR1) AMPA receptor subunit knockout mice. The present study evaluated male and female wild-type and GluR-A-/- mice on a test battery that assessed sensorimotor, affective, and cognitive behaviors. Results revealed a behavioral phenotype more extensive than previously described. GluR-A-/- mice were hyperactive, displayed a subtle lack of motor coordination, and were generally more anxious than...

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Publication status:
Published

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Publisher copy:
10.1037/0735-7044.118.3.643

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Sprengel, R More by this author
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Journal:
Behavioral neuroscience
Volume:
118
Issue:
3
Pages:
643-647
Publication date:
2004-06-05
DOI:
EISSN:
1939-0084
ISSN:
0735-7044
URN:
uuid:5f895023-eb5b-4115-9e21-909a4f9a8688
Source identifiers:
28626
Local pid:
pubs:28626

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