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NAADP controls cross-talk between distinct Ca2+ stores in the heart.

Abstract:

In cardiac muscle the sarcoplasmic reticulum (SR) plays a key role in the control of contraction, releasing Ca(2+) in response to Ca(2+) influx across the sarcolemma via voltage-gated Ca(2+) channels. Here we report evidence for an additional distinct Ca(2+) store and for actions of nicotinic acid adenine dinucleotide phosphate (NAADP) to mobilize Ca(2+) from this store, leading in turn to enhanced Ca(2+) loading of the SR. Photoreleased NAADP increased Ca(2+) transients accompanying stimulat...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m611167200

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Journal:
The Journal of biological chemistry
Volume:
282
Issue:
20
Pages:
15302-15311
Publication date:
2007-05-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:5f806e97-d0f5-4210-9df8-235be04112cb
Source identifiers:
106557
Local pid:
pubs:106557

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