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Exploring the potential of iminosugars as antivirals for Crimean-Congo haemorrhagic fever virus, using the surrogate Hazara virus: liquid-chromatography-based mapping of viral N-glycosylation and in vitro antiviral assays

Abstract:

Crimean-Congo haemorrhagic fever virus (CCHFV) is a pathogen of increasing public health concern, being a widely distributed arbovirus and the causative agent of the potentially fatal Crimean-Congo haemorrhagic fever. Hazara virus (HAZV) is a genetically and serologically related virus that has been proposed as a surrogate for antiviral and vaccine testing for CCHFV. Glycosylation analysis of HAZV has been limited; first, we confirmed for the first time the occupation of two N-glycosylation s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/pathogens12030399

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0002-7466-2977
Publisher:
MDPI
Journal:
Pathogens More from this journal
Volume:
12
Issue:
3
Article number:
399
Publication date:
2023-03-01
Acceptance date:
2023-02-22
DOI:
EISSN:
2076-0817
Language:
English
Keywords:
Pubs id:
1329556
Local pid:
pubs:1329556
Deposit date:
2023-02-22

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