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Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers

Abstract:

Pattern recognition underpins innate immunity; the accurate identification of danger, including infection, injury or tumor, is key to an appropriately targeted immune response. Pathogen detection is increasingly well defined mechanistically, but the discrimination of endogenous inflammatory triggers remains unclear. Tenascin-C, a matrix protein induced upon tissue damage and expressed by tumors, activates toll-like receptor 4 (TLR4) mediated sterile inflammation. Here, we map three sites ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-017-01718-7

Authors


Zuliani-Alvarez, L More by this author
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Department:
Oxford, MSD, NDORMS, KIR
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Department:
Oxford, MSD, NDORMS, KIR
More by this author
Department:
Oxford, MSD, NDORMS, KIR
More by this author
Department:
Oxford, MSD, NDORMS, KIR
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Grant:
Senior Fellowship: the code is 20003
Kennedy Trust for Rheumatology Research More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Pages:
Article: 1595
Publication date:
2017-11-17
Acceptance date:
2017-09-12
DOI:
ISSN:
2041-1723
Pubs id:
pubs:730422
URN:
uri:5f6575e9-0077-4cc2-a05d-1cc1bd7a35ab
UUID:
uuid:5f6575e9-0077-4cc2-a05d-1cc1bd7a35ab
Local pid:
pubs:730422

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