- Abstract:
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This project aimed to generate a mature population of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM) which would have the metabolic phenotype of cardiomyocytes in the adult heart as metabolic disorders are strongly linked with cardiovascular disease. Two published differentiation protocols were assessed, and the Wnt-modulation protocol was chosen as it upregulated the gene expression of cardiac genes. In addition, after introducing some alterations, such as tran...
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- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Copyright date:
- 2017
Thesis
Human Induced Pluripotent Stem Cells as an In Vitro model for Human Cardiomyocytes to Study Maturation and Metabolism
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