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Thesis

Human Induced Pluripotent Stem Cells as an In Vitro model for Human Cardiomyocytes to Study Maturation and Metabolism

Abstract:

This project aimed to generate a mature population of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM) which would have the metabolic phenotype of cardiomyocytes in the adult heart as metabolic disorders are strongly linked with cardiovascular disease. Two published differentiation protocols were assessed, and the Wnt-modulation protocol was chosen as it upregulated the gene expression of cardiac genes. In addition, after introducing some alterations, such as tran...

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Supervisor
Role:
Supervisor
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Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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