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Effects of chronic beta-receptor blocker treatment on cardiac high-energy phosphate metabolism in heart failure

Abstract:

In heart failure, chronic therapy with beta-receptor blocking agents improves cardiac performance and prolongs survival, but the exact mechanisms whereby these compounds exert such beneficial effects remain unclear. One hypothesis is that beta-blockers improve the energetic balance of the heart and act, at least in part, by preserving high-energy phosphate metabolism. In experimental heart failure caused by chronic coronary ligation in the rat, the beta-blocker bisoprolol significantly improv...

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Authors


Neubauer, S More by this author
Journal:
Journal of Clinical and Basic Cardiology
Volume:
3
Issue:
2
Pages:
119-122
Publication date:
2000
ISSN:
1561-2775
URN:
uuid:5f48f913-ddd1-4018-8def-2a1073f666a5
Source identifiers:
125113
Local pid:
pubs:125113
Language:
English
Keywords:

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