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A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor.

Abstract:

The inactivation of BRCA2, a suppressor of breast, ovarian and other epithelial cancers, triggers instability in chromosome structure and number, which are thought to arise from defects in DNA recombination and mitotic cell division, respectively. Human BRCA2 controls DNA recombination via eight BRC repeats, evolutionarily conserved motifs of ∼35 residues, that interact directly with the recombinase RAD51. How BRCA2 controls mitotic cell division is debated. Several studies by different group...

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Publication status:
Published

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Publisher copy:
10.1038/onc.2011.55

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Garnett, MJ More by this author
Venkitaraman, AR More by this author
Journal:
Oncogene
Volume:
30
Issue:
30
Pages:
3360-3369
Publication date:
2011-07-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:5f3a0cf3-e3ea-4b6d-b91f-67f9a7559828
Source identifiers:
124355
Local pid:
pubs:124355

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