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Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10 801 women in 17 randomised trials

Abstract:

Background After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.

Methods We undertook a meta-analysis o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author

Contributors

Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Contributor
Role:
Contributor
Role:
Contributor
Role:
Contributor
Publisher:
Elsevier
Journal:
Lancet More from this journal
Volume:
378
Issue:
9804
Pages:
1707-1716
Publication date:
2011-10-19
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Language:
English
Pubs id:
pubs:272374
UUID:
uuid:5f309702-675b-430b-8d2a-2a35a50a9dca
Local pid:
pubs:272374
Source identifiers:
272374
Deposit date:
2012-12-19

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