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Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy.

Abstract:

Cardiac troponin I (cTnI) is the inhibitory component of the troponin complex and is involved in the calcium control of heart muscle contraction. Recently, specific missense mutations of the cTnI gene (TNNI3) have been shown to cause familial hypertrophic cardiomyopathy (HCM). We have analyzed the functional effects of two HCM mutations (R145G and R162W) using purified recombinant cTnI. Both mutations gave reduced inhibition of actin-tropomyosin-activated myosin ATPase, both in experiments us...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m002502200

Authors


Elliott, K More by this author
Watkins, H More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Journal:
The Journal of biological chemistry
Volume:
275
Issue:
29
Pages:
22069-22074
Publication date:
2000-07-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:5f25a4da-70da-4378-bd39-e4be08c07906
Source identifiers:
104204
Local pid:
pubs:104204

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