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Journal article

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.

Abstract:

Parkinson's disease is a neurodegenerative disorder, characterized by accumulation and misfolding of α-synuclein. Although the level of α-synuclein in neurons is fundamentally linked to the onset of neurodegeneration, multiple pathways have been implicated in its degradation, and it remains unclear which are the critical ubiquitination enzymes that protect against α-synuclein accumulation in vivo. The ubiquitin ligase Nedd4 targets α-synuclein to the endosomal-lysosomal pathway in cultured ce...

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Publication status:
Published

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Publisher copy:
10.1016/j.nbd.2013.12.011

Authors


Davies, SE More by this author
Hallett, PJ More by this author
Mangano, E More by this author
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Journal:
Neurobiology of disease
Volume:
64
Pages:
79-87
Publication date:
2014-04-05
DOI:
EISSN:
1095-953X
ISSN:
0969-9961
URN:
uuid:5f2084c8-545c-4b49-8f95-35ce9ff4d6c2
Source identifiers:
445551
Local pid:
pubs:445551

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