Development of the Paris definition of early Crohn's disease for disease-modification trials: results of an international expert opinion process.

Journal article

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD.

Authors: Peyrin-Biroulet, L; Billioud, V; D'Haens, G; Panaccione, R; Feagan, B

• Publication status: Published
• Journal: American journal of gastroenterology
• Volume: 107
• Issue: 12
• Pages: 1770-1776
• Publication date: 2012-12-01
• DOI: 10.1038/ajg.2012.117
• EISSN: 1572-0241
• ISSN: 0002-9270
• Language: English
• Keywords: Health Knowledge, Attitudes, Practice; Inflammatory Bowel Diseases; Concept Formation; Disease Progression; Time Factors; Crohn Disease; Consensus; Clinical Trials as Topic; Severity of Illness Index; International Cooperation; Humans