Mouse fertility is enhanced by oocyte-specific loss of core 1-derived O-glycans.

Journal article

Regulation of the number of eggs ovulated by different mammalian species remains poorly understood. Here we show that oocyte-specific deletion at the primary follicle stage of core 1 beta1,3-galactosyltransferase (T-synthase; generates core 1-derived O-glycans), leads to a sustained increase in fertility. T-syn mutant females ovulated 30-50% more eggs and had a sustained increase in litter size compared to controls. Ovarian weights and follicle numbers were greater in mutants, but follicular ...

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Authors: Williams, S; Stanley, P

• Publication status: Published
• Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
• Volume: 22
• Issue: 7
• Pages: 2273-2284
• Publication date: 2008-07-01
• DOI: 10.1096/fj.07-101709
• EISSN: 1530-6860
• ISSN: 0892-6638
• Language: English
• Keywords: Genotype; Animals; Ovulation; Female; Oocytes; Galactosyltransferases; Kinetics; Core Binding Factors; Polysaccharides; Fertility; Gonadotropins; Mice